The supply of high-quality imported tobacco leaves could not meet the increasing demand in China, so State Tobacco Monopoly Administration decided to investigate the feasibility of domestic tobacco growth in favorable region in China for partial import substitution. The method of climate match index of CLIMEX was used to analysis and predict the adaptable growth region in China for tobacco leaves abroad. The results indicated that in terms of climate, 20 counties of nine provinces in China mainland were very similar to Zimbabwe and Brazil, which mainly located in Yunnan-Guizhou Plateau with mountain climate, and South China with high temperature and abundant precipitation.