A field experiment with five fertilizer treatments was carried out to study the effects of various fertilizer rates on nutrient leaching in soil in Liuyang, Hunan Province. Results indicated that NO3--N was the main part of nitrogen leaching in growth stage of flue-cured tobacco, and the content of NO3--N decreased firstly, then increased and decreased subsequently. The maximum level of NO3-N leaching was observed in the treatment of zero organic fertilizer, with potential pollution to underground water. The loss of NH4+-N by leaching was quite low, and the content of NH4+-N decreased firstly, followed by increase and decrease in lower soil layer. Significant difference occurred between different treatments, and higher ratio of organic fertilizer could reduce the leaching level of NH4+-N. Dynamic changes of potassium content appeared low to high to low subsequently, and the leaching level of soluble potassium decreased with the increasing ratio of organic fertilizer, with higher pollution rate to underground water in zero organic treatment. The organic fertilizer exceeding 20% of basal fertilizer might be favorable for less leaching of soil nutrients in South China.